Application of enamel glass lined storage tank in pharmaceuticals

In the pharmaceutical industry,the selection of equipment materials directly determines the quality,production efficiency,and compliance of drugs in the complex process chain from raw material synthesis to formulation production.The enamel glass storage tank,with its unique composite structure of"metal substrate+glass glaze layer",has become an ideal container for handling highly corrosive media,high-purity materials,and thermosensitive substances.
The enamel glass storage tank achieves the complementary advantages of metal strength and glass corrosion resistance by spraying glass glaze containing high silica on the surface of carbon steel or stainless steel substrate,and sintering at 900℃to form a dense glaze layer.The key performance indicators are as follows:
The glaze layer can resist the erosion of most inorganic acids,organic acids,and weak bases,but has poor tolerance to hydrofluoric acid and hot concentrated phosphoric acid.Glass lined storage tank can replace expensive stainless steel equipment in processes such as antibiotic fermentation broth post-treatment and vitamin C synthesis,significantly reducing investment costs.
thermal stability

The working temperature range is-30℃to 250℃,and the ability to withstand sudden temperature changes can reach cold shock≤110℃and thermal shock≤120℃.This characteristic makes it suitable for processes that require rapid heating/cooling,such as sulfonation reactions or crystallization processes.

hygienic property
The surface of the glaze layer is smooth and free of pores,meeting the requirements of GMP for"no shedding and easy cleaning".Compared to stainless steel storage tanks,enamel glass surfaces are less likely to adsorb microorganisms,which can reduce the frequency of cleaning verification and lower the risk of cross contamination.
Strong acid/strong base reaction:In the synthesis of cephalosporin antibiotics,glass lined storage tanks are used to store highly corrosive reagents such as concentrated sulfuric acid and sodium hydroxide,to prevent metal ions from infiltrating and causing excessive impurities in the product.
Oxidation reaction:The hydrogen peroxide(H₂O₂)oxidation process in vitamin E production,the enamel layer of the enamel can withstand long-term erosion by oxidizing media,extending the service life of the equipment.
Preparation production stage
High purity material storage:During the injection preparation process,glass lined storage tanks are used to temporarily store purified water,injection water,etc.Their low solubility characteristics can prevent glass components from contaminating the drug solution.
Heat sensitive substance treatment:Some biological agents need to be stored at low temperatures,and the combination of glass lined storage tanks and jacket temperature control systems can achieve temperature control.
Special process support

Regeneration of ion exchange resin:In the ion exchange resin treatment process,the enamel glass storage tank can withstand alternating flushing of hydrochloric acid and sodium hydroxide,avoiding pitting corrosion of stainless steel equipment caused by chloride ion corrosion.

Static electricity protection:For powder materials that are prone to static electricity,the enamel layer can effectively dissipate static electricity through conductive treatment,preventing the risk of porcelain or dust explosion.
Glass lined storage tanks have become the core equipment in the pharmaceutical industry for handling highly corrosive media,high-purity materials,and thermosensitive substances due to their unique corrosion resistance,thermal stability,and compliance advantages.With the increasing requirements of GMP for equipment cleanliness and traceability,glass lined storage tanks will develop towards intelligence and modularity in the future,further promoting the lean and compliance of pharmaceutical processes.